How to Say "big guns" in Spanish
The Spanish word for “big guns” is “artillería” — B2 level.
English → SpanishB2
nounB2informal
metaphorical use for powerful arguments or resources

Examples
El abogado sacó toda su artillería para ganar el caso.
The lawyer brought out all his big guns to win the case.
La empresa preparó su artillería publicitaria para el lanzamiento.
The company prepared its advertising heavy hitters for the launch.
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