How to Say "great-grandparents" in Spanish
The Spanish word for “great-grandparents” is “bisabuelo” — A2 level.

Examples
Mi bisabuelo nació en 1910.
My great-grandfather was born in 1910.
Tengo una foto antigua de mi bisabuelo en su granja.
I have an old photo of my great-grandfather on his farm.
Mis bisabuelos vinieron de Italia hace muchos años.
My great-grandparents came from Italy many years ago.
The plural 'power' of masculine nouns
Just like 'padres' can mean 'parents' and 'abuelos' can mean 'grandparents,' 'bisabuelos' can refer to a group of great-grandfathers or a mixed pair (great-grandfather and great-grandmother).
Gender and Endings
Since this word ends in '-o,' it is masculine. If you want to talk about a female great-grandmother, you must change the ending to '-a' to make 'bisabuela'.
Don't use 'Gran-abuelo'
Mistake: “Mi gran-abuelo es muy viejo.”
Correction: Mi bisabuelo es muy viejo. (Spanish uses the prefix 'bis-' instead of the word 'great' to show generations.)
Related Translations
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