How to Say "drudgery" in Spanish
The Spanish word for “drudgery” is “esclavitud” — B1 level.

Examples
Muchos países abolieron la esclavitud en el siglo XIX.
Many countries abolished slavery in the 19th century.
Luchar contra la esclavitud es un deber humano.
Fighting against slavery is a human duty.
Este trabajo es una verdadera esclavitud; no tengo tiempo para descansar.
This job is real slavery; I don't have time to rest.
Feminine Ending Pattern
In Spanish, almost all words ending in '-tud' (like salud, actitud, juventud) are feminine. You should always use 'la' or 'una' with this word.
Abstract Concept Usage
When talking about slavery as a general concept, you usually include the article 'la' (e.g., 'La esclavitud es mala') even when English would just say 'Slavery is bad'.
Gender Error
Mistake: “el esclavitud”
Correction: la esclavitud (because words ending in -tud are feminine).
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