How to Say "bloodline" in Spanish
The Spanish word for “bloodline” is “sangre” — B2 level.
English → SpanishB2
NounB2formal
Family, ancestry, or heritage.

Examples
Lleva la música en la sangre; toda su familia es de artistas.
He has music in his blood; his whole family are artists.
Es un caballo de pura sangre.
It's a pure-blood / thoroughbred horse.
Aunque nació en Canadá, tiene sangre colombiana.
Even though he was born in Canada, he has Colombian blood (heritage).
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