How to Say "drug" in Spanish
The most common Spanish word for “drug” is “droga” — use 'droga' when referring to illegal or illicit substances, often associated with recreational use or crime..
droga
/DROH-gah//ˈdɾoɣa/

Examples
La policía incautó tres kilos de droga en el aeropuerto.
The police seized three kilos of drugs at the airport.
El consumo de droga puede arruinar vidas.
Drug use can ruin lives.
Mi serie favorita es una droga; no puedo parar de verla.
My favorite series is like a drug; I can't stop watching it.
Gender and Number
'Droga' is a feminine noun, so you always use feminine articles: 'la droga' (the drug) or 'las drogas' (the drugs).
medicamento
/meh-dee-kah-MEN-toh//meðikaˈmento/

Examples
Tengo que tomar mi medicamento cada ocho horas.
I have to take my medication every eight hours.
El médico me recetó un medicamento para el dolor.
The doctor prescribed me a medicine for the pain.
¿Este medicamento tiene efectos secundarios?
Does this medication have side effects?
Masculine Noun Ending in -o
Since it ends in -o, it is almost always masculine. You should use 'el' or 'un' with it (el medicamento).
Using 'droga' instead
Mistake: “Using 'droga' to mean medicine.”
Correction: In Spanish, 'droga' usually refers to illegal substances. Use 'medicamento' or 'medicina' for health related items.
Droga vs. Medicamento
Related Translations
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