How to Say "old quarter" in Spanish
The Spanish word for “old quarter” is “casco” — B1 level. This is a very common word in everyday Spanish.
English → SpanishB1
nounB1
historic center of a city

Examples
Vamos a cenar en un restaurante del casco antiguo.
We are going to have dinner at a restaurant in the old quarter.
El ayuntamiento está situado en el casco urbano.
The city hall is located in the urban core/city center.
Fixed Phrase
When referring to the center of a city, 'casco' is almost always paired with the adjectives 'antiguo' (old/historic) or 'urbano' (urban).
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