How to Say "resign" in Spanish
The Spanish word for “resign” is “renunciar” — B1 level. This is a very common word in everyday Spanish.

Examples
Ella renunció a su trabajo para viajar por el mundo.
She resigned from her job to travel the world.
Si no estás feliz, debes renunciar a ese puesto.
If you are not happy, you should quit that post.
El director ha decidido renunciar a la presidencia.
The director has decided to step down from the presidency.
The 'A' Connection
When you specify what you are quitting, 'renunciar' almost always needs the little word 'a' (to/from) right before the thing you are giving up: 'Renunciar al trabajo' (Quit the job).
Forgetting the Preposition
Mistake: “Voy a renunciar el trabajo.”
Correction: Voy a renunciar *al* trabajo. (Remember 'al' is 'a' + 'el'.)
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