How to Say "to embitter" in Spanish
The Spanish word for “to embitter” is “envenenar” — B2 level. This is a very common word in everyday Spanish.
English → SpanishB2
verbB2
to ruin a relationship or mood

Examples
Sus celos terminaron por envenenar la relación.
His jealousy ended up poisoning the relationship.
No dejes que el odio envenene tu corazón.
Don't let hatred embitter your heart.
Esos comentarios negativos envenenaron el ambiente de la oficina.
Those negative comments poisoned the office atmosphere.
Abstract Subjects
You can use feelings or words as the subject of this verb, such as 'La envidia envenena' (Envy poisons).
Related Translations
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