How to Say "a killer" in Spanish
The Spanish word for “a killer” is “muerte” — B2 level.
English → SpanishB2
NounB2informal
informal, something very difficult or unpleasant

Examples
La llegada de internet fue la muerte del videoclub.
The arrival of the internet was the death of the video store.
¡Qué calor! Esto es la muerte.
It's so hot! This is a killer / This is torture.
Trabajar con él es la muerte; es muy exigente.
Working with him is a nightmare; he's very demanding.
Related Translations
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