How to Say "main office" in Spanish
The Spanish word for “main office” is “jefatura” — B1 level.
English → SpanishB1
nounB1
the central administrative building

Examples
Tienes que ir a la jefatura de policía para denunciar el robo.
You have to go to the police headquarters to report the robbery.
La jefatura de tráfico está en el centro de la ciudad.
The traffic department headquarters is in the city center.
Nos reunimos en la jefatura de ventas a las diez.
We are meeting at the sales headquarters at ten.
Talking about Locations
When 'jefatura' refers to a building, it is often followed by 'de' and the name of the department (e.g., Jefatura de Policía).
Using 'Headquarters' as Plural
Mistake: “Las jefaturas de policía está allí.”
Correction: La jefatura de policía está allí.
Related Translations
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