How to Say "itinerary" in Spanish
The most common Spanish word for “itinerary” is “itinerario” — use 'itinerario' when referring to a detailed plan or schedule of a journey, often including specific stops, times, and activities.
itinerario
ee-tee-neh-rah-ryohitineˈɾaɾjo

Examples
El itinerario de nuestro viaje incluye tres ciudades.
Our trip itinerary includes three cities.
Tengo un itinerario muy apretado para mañana.
I have a very tight schedule for tomorrow.
Debemos seguir el itinerario para no perder el vuelo.
We must follow the route to avoid missing the flight.
A 'He' Word
Even though it is quite long, 'itinerario' is a masculine noun. Always use 'el' or 'un' with it.
Connecting with 'De'
To say what the itinerary is for, simply use the word 'de' (of/for). For example: 'itinerario de vuelo' (flight itinerary).
Using 'Agenda' instead
Mistake: “Mi agenda de viaje es larga.”
Correction: Mi itinerario de viaje es largo. Use 'itinerario' specifically for routes and travel plans; 'agenda' is usually for business meetings or a physical planner book.
ruta
ROO-tahˈruta

Examples
Perdimos la ruta y tuvimos que usar el GPS.
We lost the route and had to use the GPS.
Esta es la ruta más rápida para llegar al aeropuerto.
This is the fastest route to get to the airport.
La ruta de autobús número cinco pasa por el centro.
Bus route number five goes through downtown.
Gender Reminder
Even though 'ruta' ends in -a, remember it is always feminine: 'la ruta' (the route).
Itinerario vs. Ruta
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