How to Say "obnoxious" in Spanish
The Spanish word for “obnoxious” is “insoportable” — B1 level. This is a very common word in everyday Spanish.

Examples
Mi jefe es insoportable; siempre está gritando.
My boss is obnoxious; he is always yelling.
Su actitud arrogante se volvió insoportable para todos.
His arrogant attitude became intolerable for everyone.
Ese niño no para de hacer ruido, ¡es insoportable!
That child won't stop making noise, he is unbearable (or: a pain)!
Gender is Easy
Since 'insoportable' ends in '-e', it is one of the adjectives that doesn't change based on whether the person or thing you are describing is masculine or feminine (e.g., 'el jefe insoportable' and 'la vecina insoportable').
Don't Change the Ending
Mistake: “insoportablo / insoportabla”
Correction: The ending remains '-able' for both genders. Only change it to 'insoportables' if you are describing more than one thing.
Related Translations
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