How to Say "mastery" in Spanish
The most common Spanish word for “mastery” is “control” — use 'control' when referring to having command or authority over a situation, project, or process..
control
/kon-trol//konˈtɾol/

Examples
El nuevo gerente tiene el control total del proyecto.
The new manager has total control of the project.
Es importante mantener el control en situaciones de estrés.
It's important to maintain control in stressful situations.
Perdió el control del coche en el hielo.
He lost control of the car on the ice.
Always Masculine
Even though it doesn't end in -o, 'control' is a masculine word. Always say 'el control' or 'un control', not 'la control'.
dominio
doh-MEE-nyoh/doˈmi.njo/

Examples
Su dominio del piano impresionó a todos en la sala.
His mastery of the piano impressed everyone in the room.
El rey tenía dominio absoluto sobre todo el territorio.
The king had absolute control over the entire territory.
Establecer un dominio completo sobre el mercado es su objetivo.
Establishing complete control over the market is their goal.
Para este puesto se requiere un dominio total del software de edición.
This position requires complete proficiency in the editing software.
Masculine Noun Rule
Remember that 'dominio' is always a masculine noun, so it takes masculine articles: 'el dominio' or 'un dominio'.
Using 'de' to Specify Skill
When talking about mastery of something, you almost always follow 'dominio' with the word 'de' (of): 'dominio del tema' (mastery of the topic).
Control vs. Dominio for Skill Mastery
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