How to Say "substance" in Spanish
The most common Spanish word for “substance” is “sustancia” — use this word for 'substance' when referring to physical matter or a chemical compound..
sustancia
/soos-TAHN-syah//susˈtansja/

Examples
El agua es una sustancia vital para la vida.
Water is a vital substance for life.
Ten cuidado, esa sustancia es pegajosa.
Be careful, that substance is sticky.
Su discurso fue largo pero no tenía mucha sustancia.
His speech was long but didn't have much substance.
Queremos llegar a la sustancia del problema.
We want to get to the core of the problem.
Gender and Articles
This is a feminine word. Always use 'la' or 'una' with it, even though it describes physical matter.
Using 'Sustancia' Figuratively
When you say a conversation 'has substance,' you mean it is serious and meaningful, not superficial.
Spelling Confusion
Mistake: “substancia”
Correction: sustancia is the most common modern spelling, though 'substancia' with a 'b' is also technically correct.
materia
/mah-TEH-reeah//maˈteɾja/

Examples
La física estudia las propiedades de la energía y la materia.
Physics studies the properties of energy and matter.
El agua puede cambiar de estado, pero sigue siendo la misma materia.
Water can change state, but it remains the same substance.
Mixing up 'materia' and 'material'
Mistake: “Usar 'la materia' para referirse a la tela o el tipo de cosa.”
Correction: Use 'el material' (the specific stuff used, like plastic or wood) instead of 'la materia' (the general concept of matter or substance) when talking about physical construction.
contenido
kon-teh-NEE-doh/kon.teˈni.ðo/

Examples
El contenido de esta página web es excelente.
The content of this website is excellent.
Antes de viajar, revisa el contenido de tu maleta.
Before traveling, check the contents of your suitcase.
Hay que crear más contenido original para el canal.
We need to create more original content for the channel.
Singular vs. Plural
In Spanish, 'contenido' (content/contents) is usually singular, even when referring to many items (e.g., the contents of a box). English often uses the plural 'contents.'
Using 'Contenidos' for Media
Mistake: “Los contenidos digitales son importantes.”
Correction: El contenido digital es importante. (While 'contenidos' is sometimes used, 'contenido' singular is much more common for general media/information.)
sustancia
/soos-TAHN-syah//susˈtansja/

Examples
Su discurso fue largo pero no tenía mucha sustancia.
His speech was long but didn't have much substance.
El agua es una sustancia vital para la vida.
Water is a vital substance for life.
Ten cuidado, esa sustancia es pegajosa.
Be careful, that substance is sticky.
Queremos llegar a la sustancia del problema.
We want to get to the core of the problem.
Gender and Articles
This is a feminine word. Always use 'la' or 'una' with it, even though it describes physical matter.
Using 'Sustancia' Figuratively
When you say a conversation 'has substance,' you mean it is serious and meaningful, not superficial.
Spelling Confusion
Mistake: “substancia”
Correction: sustancia is the most common modern spelling, though 'substancia' with a 'b' is also technically correct.
agente
/ah-HEN-teh//aˈxente/

Examples
El cloro es un potente agente blanqueador.
Chlorine is a powerful bleaching agent.
La educación puede ser un agente de cambio social.
Education can be an agent of social change.
Identificaron el agente infeccioso en el laboratorio.
They identified the infectious agent in the lab.
fondo
/fon-doh//ˈfondo/

Examples
En el fondo, sé que tienes razón.
Deep down, I know you're right.
No has entendido el fondo de la cuestión.
You haven't understood the heart of the matter.
Parece una persona fría, pero en el fondo es muy amable.
He seems like a cold person, but deep down he's very kind.
Physical Matter vs. Importance
Related Translations
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